Body--Topical Uses

ClO2-containing oxychlorine solutions could be an innovative strategy for the suppression of surgical adhesion formation, with the additional advantage of contributing antiseptic properties.

"The device comprises an optional backing layer; a chlorine dioxide source layer comprising chlorine dioxide or chlorine dioxide-generating components, and oxy-chlorine anions; and a barrier layer interposed between the chlorine dioxide source layer and the tissue, wherein the barrier layer substantially ***prohibits passage therethrough of the oxy-chlorine anions and permits passage therethrough of the substantially oxy-chlorine anion free chlorine dioxide*** composition" " In certain embodiments, the chlorine dioxide concentration ranges... most preferably from about 30 to about 200 ppm chlorine dioxide..."

Disclosed are in-the-eye uses of chlorine dioxide-containing compositions as effective ophthalmic antiseptics and as effective ophthalmic surgical irrigants.

"Chlorine dioxide gas is completely safe on stainless steel, unlike some widely used liquid chlorine dioxide solutions, whose acidic byproducts are corrosive against stainless steel." "Chlorine dioxide gas is potentially explosive at extremely high concentrations in a dry environment with an ignition source. " "One of the first commercial uses of our CD gas was to sterilize implantable contact lenses. " " Chlorine dioxide is used for the treatment of drinking water in many municipalities and also for the treatment of foods, where the use of a carcinogen would not be allowed. Formaldehyde is a confirmed human carcinogen by most international health agencies and hydrogen peroxide is a confirmed animal carcinogen"

"deodorant and a disinfectant used for a human body and having a superior deodorizing effect than conventional deodorants, particularly a deodorant and a disinfectant used for the human body quicker in drying than the conventional deodorants, giving no uncomfortable feeling when in use and suppressing a decrease in the effect caused by moisture.SOLUTION: The deodorant for the human body contains chlorine dioxide and a volatile substance, particularly contains chlorine dioxide and ethanol." " a human body deodorant composed mainly of an aqueous solution of chlorine dioxide has a problem that it feels unusable for daily use" "the deodorant of the present invention contains chlorine dioxide at a concentration of at least 1 ppm, 30 ppm and 100 ppm or more. Moreover, as a volatile substance used for the deodorizer of this invention, arbitrary volatile substances well-known to those skilled in the art can be used. In the deodorizer of the present invention, for example, alcohol such as ethanol and methanol can be used as a volatile substance. Moreover, the deodorizer of this invention can use ethers, such as a dimethyl ether, as a volatile substance. Volatile materials can be used at any concentration, but are used at concentrations that are more easily volatilized when compared to water when sprayed and applied to the human body. For example, when ethanol is used as a volatile substance, it is used at a concentration of 50%, 60% and 70% or more. In particular, when ethanol is used as a volatile substance, by using it at a concentration at which a disinfecting effect by ethanol is obtained, not only a deodorizing and disinfecting effect by chlorine dioxide but also an effect by ethanol is expected. Ethanol is known to have a high disinfecting effect when used at concentrations of 60% and 70% and above."

"penetrate debris under the nail and remove discoloration due to nail fungus."

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PURPOSE: To provide the titled remedying liquid composed of an aqueous solution containing a chlorine dioxide agent, salicylic acid and assistant components comprising a dermatic growth promoter and an antidesiccant and having advantages of easy applicability, high radical curing ratio and rapid hair growth... EFFECT: It has strong drug action and the infection to man can be completely prevented by the use of a sprayer, etc.

A chlorine dioxide liquid agent comprising dissolved chlorine dioxide gas as a constituent, which is used as a remedy for skin diseases and mucosal diseases to be applied to an infected area in order to improve symptoms of an infected area caused by infection with a pathogenic microorganism Infectious skin and mucous membrane diseases.

****!!!!**** "The chlorine dioxide solution contains dissolved chlorine dioxide gas as a constituent component." " sodium chlorite and potassium chlorite are preferred, and sodium chlorite is most preferred, not only for the reasons of easy availability, but also from the viewpoint of excellent sustainability of chlorine dioxide activity." "acne vulgaris... Chlorine dioxide concentration at the time of dilution: 150 ppm)" "chlorine dioxide liquid with a concentration of 10 ppm or more will inactivate adenoviruses that cause epidemic keratoconjunctivitis, and it is disclosed that the chlorine dioxide liquid does not affect the eyeball even at a concentration of 250 ppm." " By selecting sodium dihydrogen phosphate or a mixture of sodium dihydrogen phosphate and disodium hydrogen phosphate, and using it in combination with sodium chlorite, the storage stability is further improved" "In this way, unnecessary consumption of sodium chlorite is suppressed and sodium chlorite is effectively consumed, so the storage stability is further improved (prolonged), and the concentration of chlorine dioxide fluctuates over time (variation) during storage. ) Is further reduced (not only the decrease in concentration is suppressed, but the increase in concentration is also suppressed"

"also relates to compositions that are useful for topical application, especially to nails and adjacent tissue for the treatment of mycotic and microbial infections." "In additon to the treatment of microbial and mycotic infections, the antimicrobial compositions of the present invention also serve to rid the treatment area of cellular debris that accumulates as a result of the infection." "may further comprise... surfactants... used to stabilize the chlorine dioxide compound in an aqueous solution." "those with the worst nail condition at the beginning showed the highest percentage improvement over the four week period."

"Topically, the tetrachlorodecaoxygen anion complex (TCDO) has a therapeutic effect in wound healing [2, 9] with an increase of pO2 in the capillary blood [3] and systematically in experimental infections [1], It constitutes a negatively charged complex of chlorine and oxygen (Cl4O10)n, MWn=1 = 301.8. Incubation with hemoproteins leads to complex degradation and the appearance of oxygen water in chloride [4], whereby toxic oxygen species are not formed [8]. Heme-ac-tivated TCDO was described to be bactericidal for a number of microbial species [6, 7], to enhance phagocytosis by resident peritoneal macrophages of mice [7], and to stimulate humoral and cellular immunity [1]."

Werner, Sabine, and Richard Grose. Regulation of Wound Healing by Growth Factors and Cytokines. Physiol Rev 83: 835–870, 2003; 10.1152/physrev.00032.2002.—Cutaneous wound healing is a complex proce...

"15 patients who were treated with Vacuum-Assisted Closure (VAC) negative pressure therapy system"

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"contacting a stable precursor with a transition metal in a buffered aqueous medium."

"63 transcutaneous measurements of oxygen pressure and 36 series of infrared thermograms in 9 hypoxic wounds showed that topical administration of tetrachlorine decaoxide (TCDO) results in increased oxygen supply of the wound. This effect is associated with improvement of the skin temperature and decrease of the pathological temperature difference between the wound and the surrounding tissue. TCDO can induce physiological wound healing, since it improves the mechanisms of the immune defence system, wound cleansing, granulation, and epithelialization in slow-healing wounds."

{Regard sodium chlorite contact lens solution}

To evaluate the efficacy and safety of newly formulated brimonidine (0.1% brimonidine tartrate preserved with sodium chlorite: brimonidine) as add-on therapy in on-treatment Japanese normal-tension glaucoma (NTG) patients.Brimonidine was added to on-treatment ...

"In 1986, a randomized controlled trial (RCT) has shown that moist dressing with a sodium chlorite (NaClO2)-based drug is beneficial for rapid wound cleansing and granulation [3]. If not further concentrated under vacuum (which is commonly practiced with industrial NaClO2), pharmaceutical chlorite contains a chlorine peroxide contaminant, formerly called tetradecachlorooxygen (TCDO), a chemical name refuted by the German Health Authorities [4]. The chlorine peroxide seems to be important for systemic regenerative effects in stem cell compartments of rats [5],[6]. Recent advances in bacterial heme protein biochemistry [7],[8] have reformed our understanding of chlorite biochemistry [9] showing that in vivo reactions of chlorite with heme analogues can either produce hypochlorite, which in turn can react with H2O2 to form singlet oxygen 1O2, or which can dismutate to Cl- and 1O2. In animal experiments with non-thermal (NTP) [10] or cold atmospheric plasma (CAP) [11] lower μM levels 1O2 have shown to induce wound healing."

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